Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1170 | 1170-30305 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, M230L | V108I | E44D, S68G, K122P, I135V, K166R, D177E, T200TA, R211K, V245A |
| >1170-30305| codons 38-247 CTELEKDGKISKIGPENPYNTPVFAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDPDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTP DKKHQKEPPFLWLGYELHPDKWTVQPIALP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, L90M | L23I, K43T, F53L, N88D | L10I, K20R, E35D, M36I, R57K, I62V, L63P, A71V |
| >1170-30305| codons 4-99 TLWQRPIVTIKIGGQLREAILDTGADDTVLEDINLPGRWTPKMIGGIGGLVKVKQYDQVP IEICGHKVIGTVLVGPTPANIIGRDLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |