Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1169 | 1169-30304 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I50V, I54V, V82A, L90M | L33F, Q58E, G73GC, L89LV | L10I, T12I, I13V, G16A, E35D, M36I, N37D, D60E, I62V, L63P, A71V |
| >1169-30304| codons 4-99 TLWQRPIVIVKIAGQLKEALLDTGADDTVFEDIDLPGRWKPKMIGGVGGFVKVREYEQVP IEICGHKVICTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | T39A, K43E, E44D, W88C, V118I, K122E, I135L, S162Y, D177E, G196E, T200TS, E203K, Q207E, R211K, V245Q |
| >1169-30304| codons 38-247 CAELEEDGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFCEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRSKIKELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |