<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1906 1906-30616 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46MI, I47V, I54V, V82A, L90M L33F, K43T, F53L L10IV, I13IV, K20R, E35D, M36I, D60E, I62V, L63P, A71V, I93L  
>1906-30616| codons 4-99
TLWQRPVVTVKIGGQLREALLDTGADDTVFEDINLPGRWTPKIVGGIGGLVKVRQYEQVP
IEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y K219R K103N A98G K43Q, E44D, V118I, K122E, S162C, Q174QR, D177E, I178IM, V179VI, G196E, E203K, Q207E, R211K, K223E, L228H, Q242H  
>1906-30616| codons 38-247
CTELEQDGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
GGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRKRNPEMIIYQYVDDLYVGSDLEIEQHRTKIKELREHLWKWGFYTP
DRKHQEEPPFHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006