<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1904 1904-30512 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
K65R, K70R, Q151M V75I, F77L, F116Y, T215C, K219Q Y181C, Y188L   S68G, T69K, K101Q, D121Y, K122E, D123E, T139M, I178IM, V179I, V189I, H208Y, D218E, P243S, V245K  
>1904-30512| codons 38-247
CTEMEKEGKISKIGPENPYNTPVFAIKRKDGKRWRKLIDLRELNKRTQDFWEVQLGIPHP
AGLQKKKSVTVLDVGDAYYSVPLYEEFRKYTAFTIPSINNEMPGIRYQYNVLPMGWKGSP
AIFQSSMTKILEPFRKQNPDMIICQYMDDLLIGSDLEIGQHRTKIEELRQYLLRWGFCTP
EQKHQKEPPFLWMGYELHPDKWTVQSIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I54L, V82A, L90M L10F, F53FL, Q58E, G73C, L89V L19LI, L33M, L38LW, K55R, D60E, I62IV, L63P  
>1904-30512| codons 4-99
TLWQRPFVTIKIGGQIKEALLDTGADDTIMEEMNWPGRWKPKIIGGIGGLLRVREYEQVP
IEICGHKAICTVLVGPTPANIIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006