Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1904 | 1904-30512 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54L, V82A, L90M | L10F, F53FL, Q58E, G73C, L89V | L19LI, L33M, L38LW, K55R, D60E, I62IV, L63P |
| >1904-30512| codons 4-99 TLWQRPFVTIKIGGQIKEALLDTGADDTIMEEMNWPGRWKPKIIGGIGGLLRVREYEQVP IEICGHKAICTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, K70R, Q151M | V75I, F77L, F116Y, T215C, K219Q | Y181C, Y188L | S68G, T69K, K101Q, D121Y, K122E, D123E, T139M, I178IM, V179I, V189I, H208Y, D218E, P243S, V245K |
| >1904-30512| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKRKDGKRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDVGDAYYSVPLYEEFRKYTAFTIPSINNEMPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDMIICQYMDDLLIGSDLEIGQHRTKIEELRQYLLRWGFCTP EQKHQKEPPFLWMGYELHPDKWTVQSIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |