Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1168 | 1168-30505 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54L, V82A, L90M | L10F, L33F | N37D, L63P, H69Q, A71V, I72V |
| >1168-30505| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTIFEEMDLPGRWKPKIIGGIGGFLKVRQYDQIP IEICGQKVVGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K103N | A98G, Y188F | K43E, E44A, V60I, R83K, V118I, K122E, I135V, E138A, S162C, G196E, R211K, V245M |
| >1168-30505| codons 38-247 CTELEEAGKISKIGPENPYNTPIFAIKKKNSDKWRKLMDFRELNKKTQDFWEVQLGIPHP GGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNATPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYVDDLFVGSDLEIEQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |