Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1166 | 1166-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L33F | L10I, I13V, K20R, E35D, M36I, N37ND, R41RK, K55KR, D60E, I62IV, L63P, I64V, K70T, A71V, I72T, L89M, I93L |
| >1166-30317| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEDIDLPGKWKPKIIGGIGGFVRVRQYEQVP VEICGHTVTGTVVVGPTPVNVIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L210W, T215Y | D67G, K219E | K43E, E44A, S68G, V106VI, V118VI, K122E, S162C, E203D, H208Y, R211RK, L228H |
| >1166-30317| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKGGTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIDELRQYLWKWGFYTP DEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |