Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1161 | 1161-30529 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, L74LV, Y115YF, Q151M | A62V, K70T, V75I, F116Y | K103S, G190A | V60I, S68G, T69I, R83K, V118I, K122P, D123E, I135IT, T139I, R172K, Q174R, D177E, I178IM, D192DN, Q197E, E204K, Q207E, R211K, F214L |
| >1161-30529| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFVIKRKDGITWRKVIDFRELNKKTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAFYSIPLDPEFRKYTAFTIPSTNNEIPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFKKRNPEMVIYQYMDDLYVASNLEIGEHRTKIEKLREHLLKWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47A, L90M | L23LI, F53FL | L10V, K20R, E35D, M36I, N37E, L63P, A71LV, V77I, I93L |
| >1161-30529| codons 4-99 TLWQRPVVTIKIGGQLREAILDTGADDTILEDIELPGRWKPKIAGGIGGLIKVRQYDQIP IEICGHKVIGTVLIGPTPVNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |