Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2180 | 2180-30721 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, M36I, N37DE, I62IV, L63A, I72V |
| >2180-30721| codons 4-99 TLWQRPLVTIKIGGQLKEALLDTGADDTVLEDIELPGRWKPKMIGGIGGFIKVRQYDQVA IEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| A62AV, V75VI | E79D, R83K, K122E, D123N, K166KR, I178L, I202V, H208Y, R211K |
| >2180-30721| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKDSTKWRKLIDFRDLNKKTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPDLVIYQYMDDLYVGSDLEIGQHRTKVEELRQYLLKWGFTTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |