Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2060 | 2060-30626 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, L90M | K43T | L10V, I13V, K14KR, Q18K, K20KM, E35ED, M36I, N37D, D60E, I62V, L63P, I64V, K70R, T91TS |
| >2060-30626| codons 4-99 TLWQRPVVTVRIGGKLMEALLDTGADDTVLEDIDLPGRWTPKMIVGIGGFVKVRQYEQVP VEICGHRAIGTVLVGPTPANIIGRNLMSQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | A62V, D67T, V75I, F77L, F116Y, K219Q | Y181I | V108I | S68G, T69X, K101Q, L109I, S162Y, Q174QR, V179I, V189VI, T200A, I202V, E203K, Q207E, L210F, R211K, D218E, K223Q, L228H, P243S, V245E |
| >2060-30626| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKTGXKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLQKKKSVTIIDVGDAYYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQYSMTKILEPFRKRNPDIIIIQYMDDLYIGSDLEIGQHRAKVKELREHLFKWGFTTP EQKHQQEPPFHWMGYELHPDKWTVQSIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |