Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2057 | 2057-30623 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219N | Y181C, G190A | K101H, F227L | K43E, E44A, V106I, V118I, K122E, I135T, G196E, Q197K, T200A, E203D, H208Y, R211K, H221Y |
| >2057-30623| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIEKHRAKIDELRQYLWKWGFYTP DNKYQKEPPLLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, I84V, L90M | L10F, L33F, G73T | I13V, L19I, E34Q, K55R, I62V, L63P, I66F, H69Q, V77VI |
| >2057-30623| codons 4-99 TLWQRPFVTVKIGGQIKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFLRVRQYDQVP IEFCGQKAITTVLIGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |