<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-2041 2041-30603 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
G48GMRV, I54V, V82A, L90M F53L, G73GS L10I, N37ND, Q61QH, L63P, I66IV, A71AV, I72V, V77VI, I93L, C95CF  
>2041-30603| codons 4-99
TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIVGIGGLVKVRQYDHIP
IEVCGHKVVSTVLIGPTPANIIGRNLMTQLGFTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, T69D, L74I, L210W, T215Y D67DG, K219R K101E, Y181C, G190A A98G, V108VI, E138EK T39AE, E44D, K64H, V118I, K122E, T200A, E203ED, Q207D, H208HY, R211K, H221HY, L228H  
>2041-30603| codons 38-247
CEELEKDGKISKIGPENPYNTPVFAIHKKGSDKWRKIVDFRELNKRTQDFWEVQLGIPHP
GGLEKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNKTPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRAKIDELRDYLWKWGFYTP
DRKYQKEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006