Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2041 | 2041-30603 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48GMRV, I54V, V82A, L90M | F53L, G73GS | L10I, N37ND, Q61QH, L63P, I66IV, A71AV, I72V, V77VI, I93L, C95CF |
| >2041-30603| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIVGIGGLVKVRQYDHIP IEVCGHKVVSTVLIGPTPANIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, L74I, L210W, T215Y | D67DG, K219R | K101E, Y181C, G190A | A98G, V108VI, E138EK | T39AE, E44D, K64H, V118I, K122E, T200A, E203ED, Q207D, H208HY, R211K, H221HY, L228H |
| >2041-30603| codons 38-247 CEELEKDGKISKIGPENPYNTPVFAIHKKGSDKWRKIVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNKTPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYMDDLYVASDLEIGQHRAKIDELRDYLWKWGFYTP DRKYQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |