Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2040 | 2040-30603 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, M184V, T215F | K219Q | Y188L | T39A, V106I, V118I, K122E, D123E, I135T, T165I, T200I, R211K, F214L, D218E, L228H |
| >2040-30603| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSITVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMIKILEPFRKQNPDIVIYQYVDDLLVGSDLEIGQHRIKIEELRQHLLKWGLFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54A, V82A, L90M | L10F, V11VI, L33LI, K43KT, G73GS, L89V | I13V, K14KR, Q18H, K20I, E35D, M36I, N37D, I62V, L63P, A71I, I72L |
| >2040-30603| codons 4-99 TLWQRPFITVRIGGHLIEALLDTGADDTVIEDIDLPGRWTPKMIGGIGGFAKVRQYDQVP IEICGHKILSTVLVGPTPANIIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |