Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2039 | 2039-30602 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | V11I, L33F | L10I, I13V, E35D, M36I, N37Q, R41K, K55R, I62V, L63P, A71T, I72L, G73V |
| >2039-30602| codons 4-99 TLWQRPIITVKIGGQLKEALLDTGADDTIFEDIQLPGKWKPKIVGGIGGFLRVRQYDQVP IEICGHKTLVTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | K219N | K101E, Y181C, G190A | A98G, V108I | T39A, K43E, S68G, V118I, D123E, I135T, T200TI, H208Y, R211K, D218E, K223Q, V245VE |
| >2039-30602| codons 38-247 CAELEEEGKISKIGPENPYNTPVFAIKKKNGTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVTILDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRIKIEELRQYLLKWGFYTP ENKHQQEPPFLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |