Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1949 | 1949-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82T, I84V, L90M | L10F, L33F, G73S | I13V, L24F, I62V, L63P, A71V, I72V |
| >1949-30528| codons 4-99 TLWQRPFVTVKIGGQLKEALFDTGADDTVFEEMNLPGRWKPKIIGGIGGFIKVRQYDQVP IEICGHKVVSTVLVGPTPTNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, K70KR, M184V, T215FY | K219KQ | T69TN, A98S, I135T, I202V, H208HY, R211K, L228LH, V245R |
| >1949-30528| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKVEELRQYLLKWGFYTP DQKHQKEPPFHWMGYELHPDKWTVQPIRLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |