Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1948 | 1948-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54AV, V82A, I84V, L90M | L33F, Q58E, G73GS | L10I, T12P, I13IV, L19T, D60E, I62V, L63P, I66IV, A71T, V75VI, V77I, T91S, I93L, C95F |
| >1948-30528| codons 4-99 TLWQRPIVPVKIGGQTKEALLDTGADDTVFEEMNLPGRWKPKMIVGIGGFVKVREYEQVP IEVCGHKTISTILIGPTPANVIGRNLMSQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | V75S, K219Q | K101P, G190A | T39N, K64H, V118I, K122E, I135T, D177E, V179I, I180V, T200A, H208Y, R211K, D218E, L228H |
| >1948-30528| codons 38-247 CNELEKEGKISKIGPENPYNTPVFAIHKKNSTKWRKVSDFRELNKRTQDFWEVQLGIPHP AGLPKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIIVYQYVDDLYVASDLEIGQHRAKIEELRQYLWKWGFYTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |