Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1946 | 1946-30528 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54S, V82A, I84V, L90M | L33F | L10I, I13V, E34Q, N37D, L63P, I66F, A71V, Q92K |
| >1946-30528| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFQEMDLPGRWKPKIIGGIGGFSKVRQYDQIP IEFCGHKVIGTVLVGPTPANVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74LI, V75M, M184V, L210W, T215F | K103N | K43E, K122E |
| >1946-30528| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIKKKNSTKWRKIMDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWRWGFFTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |