Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1917 | 1917-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48GA, I54V, V82A | L24I, L33F, G73GS | L10I, K20R, E35D, M36I, R41K, K55KR, R57K, D60E, I62V, L63P, A71V, I72IT, I93IL |
| >1917-30519| codons 4-99 TLWQRPIVTIKIGGQLREALIDTGADDTVFEDINLPGKWKPKLIAGIGGFVRVKQYEQVP IEICGHKVTSTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, M184V, L210W, T215Y | K219N | G190A | K43E, E44A, V90VI, V118I, K122E, I142V, T200I, E203D, H208Y, R211RK, V245K |
| >1917-30519| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKIVDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIGQHRIKIDELRQYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |