Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1510 | 1510-30519 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70E, L74V, M184V, T215Y | K101E, Y181C, G190A | K43E, V60I, K122E, I135T, S162Y, T200A, E224ED |
| >1510-30519| codons 38-247 CTELEEEGKISKIGPENPYNTPIFAIKKKNSTEWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRAKIEELRQHLLRWGFYTP DKKHQKDPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L33F | L10I, G16A, N37NS, R41RK, I62V, L63P, I66F, C67Y, A71T, I72R, I93L, C95F |
| >1510-30519| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTVFEEMSLPGKWKPKLIGGIGGFVKVRQYDQVP IEFYGHKTRGTVLVGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |