Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1508 | 1508-30515 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A | L10I, K20KR, M36MI, L63P, A71V, I72V, I93M |
| >1508-30515| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTVLEEINLPGRWKPKLIVGIGGFTKVRQYDQIP IEICGHKVVGTVLVGPTPANIIGRNLLTQMGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | T215V, K219Q | K238T | D123E, K166R, D177E, I178L, T200A, I202V, V245E |
| >1508-30515| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPELVIYQYMDDLYVGSDLEIGQHRAKVEELRQHLLRWGFVTP DQKHQKEPPFLWMGYELHPDTWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |