Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1505 | 1505-30515 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Q151M | A62V, V75I, F77L, F116Y | Y181C | S68G, K166R, F214L, V245T |
| >1505-30515| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMTRILEPFRKQNPDIVICQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, V82A, I84V | L33F, G48E, Q58E | L10I, I13V, I15IV, K20R, E35D, M36I, N37S, R41K, K55R, R57K, D60E, L63P, A71V, I93L |
| >1505-30515| codons 4-99 TLWQRPIVTVKVGGQLREALLDTGADDTVFEDISLPGKWKPKIIEGIGGFMRVKEYEQIP IEICGHKVIGTVVVGPTPANVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |