Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1501 | 1501-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, Q151M, M184I, T215Y | K70Q | Y188L | V60I, V118I, K122E, I135L, I142T, V179I, T200A, H208Y, R211RK, F214L, K223Q |
| >1501-30527| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTQWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSLNNETPGTRYQYNVLPMGWKGSP AIFQSSMTKILEPFRKQNPDIIIYQYIDDLLVGSDLEIGQHRAKIEELRQYLLKWGLYTP DKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54L, I84V, L90M | L10F, L33F, Q58E, G73GS, L89V | E34Q, D60DEKN, L63P, H69Q, K70KE, A71V, I93L |
| >1501-30527| codons 4-99 TLWQRPFVTIKIGGQLKEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFLKVREYNQIP IEICGQEVISTVLVGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |