Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1500 | 1500-30508 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, V11I, G73S, L89V | T12S, I13V, I15V, L19P, K20I, M36I, R41K, G51A, I62IV, L63P, A71V, I72L, P79A |
| >1500-30508| codons 4-99 TLWQRPFISVKVGGQPIEALLDTGADDTVLEEINLPGKWKPKIIGGIAGFMKVRQYDQVP IEICGHKVLSTVLVGATPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184MV, L210W, T215Y | V75M, F77L | K103N | T39A, K43E, V60I, V118I, K122E, I135T, T200A, R211K |
| >1500-30508| codons 38-247 CAELEEEGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |