Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1154 | 1154-30722 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215F | K219Q | K101P, G190A | T69N, K122E, D123N, I135M, E169D, R211K, L228H |
| >1154-30722| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSNKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLPKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKQNPDIVIYQYVDDLYVASDLEIGQHRTKIEELRQHLLKWGFFTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47V, I54L, I84V, L90M | L33F, G73ST, L89LV | L10I, I15V, L19LI, K20R, E34EV, E35D, M36I, N37D, K55KR, I62V, L63P, A71V |
| >1154-30722| codons 4-99 TLWQRPIVTIKVGGQIREALLDTGADDTIFVDIDLPGRWKPKIVGGIGGFLRVRQYDQVP IEICGHKVITTVLVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |