Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1153 | 1153-30709 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219N | Y181C, G190A | F227L | T39TA, K43N, E44D, V106I, L109LI, V118I, D123E, I135IT, S162Y, E169D, V179I, H208Y, R211RK, D218E, H221Y | K101LV |
| >1153-30709| codons 38-247 CAELENDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLVKKKSITVIDVGDAYFSIPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILDPFRKQNPDIIICQYMDDLYVASDLEIGQHRTKIEELRQYLWKWGFYTP ENKYQKEPPLLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82S, L90M | V11VI, L33LF, G73T | L10I, K20IM, E34Q, E35D, M36I, D60E, I62V, L63P, C67L, A71V, I72L |
| >1153-30709| codons 4-99 TLWQRPIITIKIGGQLMEALLDTGADDTVFQDINLPGRWKPKMIVGIGGFVKVRQYEQVP IEILGHKVLTTVLVGPTPSNIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |