Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1152 | 1152-30701 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V | L10F, L23I, L33F, F53L, G73GS | I13V, G16GA, N37ND, L63P, V77I, I93L |
| >1152-30701| codons 4-99 TLWQRPFVTVKIAGQLKEAILDTGADDTVFEEMDLPGRWKPKIIGGVGGLIKVRQYDQIP IEICGHKAISTVLIGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Y115F, Q151M, M184V, T215Y | A62V, V75I, F77L, F116Y, K219Q | K103N | A158S, D177N, G196E, I202IV | W229G |
| >1152-30701| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAFYSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP SIFQSSMTKILEPFRKQNPNIVIYQYVDDLYVGSDLEIEQHRTKVEELRQHLLRWGFYTP DQKHQKEPPFLGMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |