<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1151 1151-30514 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, I84V L10F, V11VI, L24I, L33F, L89LV I13V, K55R, R57K, D60DE, L63P, A71L, I72IT, I93L T91TCS
>1151-30514| codons 4-99
TLWQRPFITVKIGGQLKEALIDTGADDTVFEEMNLPGRWKPKLIGGIGGFVRVKQYEQIP
IEICGHKLTGTVLVGPTPANVIGRNVLSQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74LV, M184V, L210W, T215Y V75VIM, F77FL, K219KR L100LI, K103KN A98G, V108VI T39K, K43E, E44D, R83K, V118I, K122E, D123E, D177G, V179I, G196E, E203K, Q207E, H208Y, R211K, K223T, L228R  
>1151-30514| codons 38-247
CKELEEDGKISKIGPENPYNTPVFAIKKKDSTKWRKVMDLRELNKKTQDFWEVQLGIPHP
GGIKKNKSVTILDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPGIIIYQYVDDLYVGSDLEIEQHRTKIKELREYLWKWGFYTP
DRKHQTEPPFRWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006