Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1496 | 1496-30610 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | K101E, Y181C, G190A | A98G, V108VI, F227FL | T39A, K43E, E44A, K64R, R83K, V111VIM, V118I, K122E, D123DGNS, I135T, I195L, G196E, E203K, H208Y, K223E, L228H |
| >1496-30610| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHP GGLEKKKSVTILDMGDAYFSIPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLELEQHRTKIKELRQYLWRWGFYTP DNKHQEEPPLHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32VI, M46MI, I47IV, I54M, L76LV, I84V, L90M | L33F, G73GS, L89V | L10IV, I13V, I15V, Q18H, E34EV, E35D, M36IL, K55KR, I62IV, L63P, A71V, I72ILM |
| >1496-30610| codons 4-99 TLWQRPVVTVKVGGHLKEALLDTGADDTIFVDLNLPGRWKPKIVGGIGGFMRVRQYDQVP IEICGHKVMSTVVVGPTPVNVIGRNVMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |