<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1496 1496-30610 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N K101E, Y181C, G190A A98G, V108VI, F227FL T39A, K43E, E44A, K64R, R83K, V118I, K122E, D123DGNS, I135T, I195L, G196E, E203K, H208Y, K223E, L228H V111VIM
>1496-30610| codons 38-247
CAELEEAGKISKIGPENPYNTPVFAIRKKNSTKWRKVVDFRELNKKTQDFWEVQLGIPHP
GGLEKKKSVTILDMGDAYFSIPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLELEQHRTKIKELRQYLWRWGFYTP
DNKHQEEPPLHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32VI, M46MI, I47IV, I54M, L76LV, I84V, L90M L33F, G73GS, L89V L10IV, I13V, I15V, Q18H, E34EV, E35D, M36IL, K55KR, I62IV, L63P, A71V, I72ILM  
>1496-30610| codons 4-99
TLWQRPVVTVKVGGHLKEALLDTGADDTIFVDLNLPGRWKPKIVGGIGGFMRVRQYDQVP
IEICGHKVMSTVVVGPTPVNVIGRNVMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006