<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1493 1493-30502 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82S, L90M L10FY, L33F, K43T, F53L, T74P I13V, L19I, K20R, E35D, M36I, N37E, R41K, I62V, L63P, I66F, A71V, I72IV  
>1493-30502| codons 4-99
TLWQRPYVTVKIGGQIREALLDTGADDTVFEDIELPGKWTPKMIGGIGGLVKVRQYDQVP
IEFCGHKVVGPVLVGPTPSNIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, L210W, T215Y K70N, K219R K103N, Y181C   E40F, K43E, T69N, V118I, K122E, D123E, I142V, V179T, G196E, T200A, H208Y, R211K, W212M, D218E, L228H, Q242H  
>1493-30502| codons 38-247
CTFLEEEGKISKIGPENPYNTPVFAIKKKDSNNWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDITICQYMDDLYVGSDLEIEQHRAKIEELRQYLWKMGFYTP
ERKHQKEPPFHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006