Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1761 | 1761-30410 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74IV, Y115F, M184V | D67DG, K219E | K101E, Y181C, G190A | V108I | I50V, V118VI, K122E, G196K, Q197K, R211K, H221Y, V245M |
| >1761-30410| codons 38-247 CTEMEKEGKISKVGPENPYNTPVFAIKKKGSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTILDVGDAFFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIKKHRTKIEELRQHLLKWGFTTP DEKYQKEPPFLWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, I84V, L90M | V11VIL, L33F, K43T, T74P | L10I, I13V, K20R, E35D, M36I, N37E, K55R, I62V, L63P, A71V, I93L |
| >1761-30410| codons 4-99 TLWQRPILTVKIGGQLREALLDTGADDTVFEDIELPGRWTPKIIGGIGGFVRVRQYDQVP IEICGHKVIGPVLVGPTPANVIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |