Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1490 | 1490-30327 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | V11VI, G73T | L10I, I13IV, K14KR, I15V, K20I, M36I, I62V, L63P, A71IV, I72IR, P79D, I85V, T91S, I93L |
| >1490-30327| codons 4-99 TLWQRPIITVRVGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKVRTTVLVGDTPVNVVGRNLMSQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219D | Y181C, Y188L | K43E, E44A, K102Q, V118I, K122E, D123DN, T139K, S162A, T165I, Q197K, T200A, D218E, L228H |
| >1490-30327| codons 38-247 CTELEEAGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKQKKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSINNEKPGIRYQYNVLPQGWKGSP AIFQASMIKILEPFRKQNPDIVICQYMDDLLVGSDLEIGKHRAKIEELRQHLWRWGFYTP EDKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |