Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1272 | 1272-30721 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, L210W, T215Y | K219N | K101KE | F227L | K43Q, E44D, V118I, K122E, L187F, E203K, H208Y, R211K, K223E | Q182QP, D186H |
| >1272-30721| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYPYMDHFYVGSDLEIGQHRTKIKELRQYLWKWGFYTP DNKHQEEPPLLWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46ML, I54V, V82A, L90M | L33F, F53FL, Q58QE | L10I, L19V, E35ED, M36L, N37S, R57RK, I62V, L63P, C67CY, A71V |
| >1272-30721| codons 5-99 LWQRPIVTIKIGGQVKEALLDTGADDTVFEDLSLPGRWKPKLIGGIGGLVKVKEYDQVPI EIYGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |