<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1860 1860-30520 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, V82A, I84V L24I, L33F L10I, L19LI, E35D, N37S, I62V, L63P, A71V, T91S  
>1860-30520| codons 4-99
TLWQRPIVTIKIGGQIKEALIDTGADDTVFEDMSLPGRWKPKIIGGIGGFVKVRQYDQVP
IEICGHKVIGTVLVGPTPANVIGRNLLSQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L210W, T215Y K219KR     K43Q, V60I, K122E, I135V, Q145M, K166R, T200E, E203K, Q207E, R211K  
>1860-30520| codons 38-247
CTELEQEGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYMYNVLPQGWKGSP
AIFQSSMTRILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHREKIKELREHLWKWGFYTP
DRKHQKEPPFLWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006