Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1473 | 1473-30428 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54L, L90M | L10F, L33F, G73T | T12N, E34Q, K55N, I62V, L63P, A71T, I72M, V77I |
| >1473-30428| codons 4-99 TLWQRPFVNIKIGGQLKEALLDTGADDTIFQEMNLPGRWKPKMVGGIGGFLNVRQYDQVP IEICGHKTMTTVLIGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Q151M | K219Q | K103N | V60I, D123E, I135T, R172RK, Q174R, D177E, G196E, T200A, F214L, L228H, V245E |
| >1473-30428| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFKKRNPEIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGLTTP DQKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |