Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1471 | 1471-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54A, V82VA, I84V, L90M | L10FY, L33F, T74P | Q18H, L19I, K20R, E34Q, E35D, M36I, N37D, I62V, L63P, A71V, I72IT, Q92QK |
| >1471-30424| codons 4-99 TLWQRPYVTIKIGGHIREALLDTGADDTVFQDIDLPGRWKPKIIGGIGGFAKVRQYDQVP IEICGHKVTGPVLVGPTPANVIGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K103N | T39A, E44D, V118I, K122E, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, V245VE |
| >1471-30424| codons 38-247 CAELEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTP DNKHQEEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |