Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1472 | 1472-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I84V, L90M | L10F, L33IM, N88D | I13V, E35D, M36I, K55R, R57K, I62V, L63P, I66V, A71V, I72L, V77T, I93L, C95F, F99Y |
| >1472-30424| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADDTIMEDINLPGRWKPKIVGGIGGFIRVKQYDQVP IEVCGHKVLGTVLTGPTPVNVIGRDLMTQLGFTLNY |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K219R | Y188L | A98G | K43N, E44D, V60I, K102Q, V106I, V118I, K122E, I142V, G196E, E203V, H208Y, R211K, K223E, L228H, V245E | W71WR |
| >1472-30424| codons 38-247 CTELENDGKISKIGPENPYNTPIFAIKKKNSTKRRKLMDFRELNKRTQDFWEVQLGIPHP GGLKQKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLLVGSDLEIEQHRTKIVELRQYLWKWGFYTP DRKHQEEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |