Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1469 | 1469-30422 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54IV, V82A, L90M | V11IL, L33F, F53L | L10I, I15V, K20V, L24F, E35N, M36I, R41K, K45KR, K55KR, D60E, I62V, L63P, A71I, I85IV, L89LIM |
| >1469-30422| codons 4-99 TLWQRPILTIKVGGQLVEALFDTGADDTVFENINLPGKWKPRMIGGIGGLVRVRQYEQVP IEICGHKIIGTVLVGPTPANIVGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, V75M, M184V, L210W, T215Y | K219Q | K103N | A98G | T39K, K43E, V60I, V111I, V118VI, K122E, I135IL, Q145QK, D177DE, T200TA, E203K, Q207E, H208Y, R211K, K223Q, L228H |
| >1469-30422| codons 38-247 CKELEEEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTVLDIGDAYFSIPLDEDFRKYTAFTIPSLNNETPGIRYKYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTP DQKHQQEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |