Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1758 | 1758-30710 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, I54V, L76V, V82C, I84IV | L10IV, I15IV, L19I, K20R, E35D, M36I, N37D, D60E, Q61EK, I62IV, L63P, A71V, I93L |
| >1758-30710| codons 4-99 TLWQRPVVTIKVGGQIREALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVKVRQYEKVP IEICGHKVIGTVVVGPTPCNVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K43KQ, V118I, K122E, S162A, K173T, G196GE, Q207E, R211K, P243S, V245T |
| >1758-30710| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRTQNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELREHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQSITLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |