Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1288 | 1288-30408 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, T215FL | A62V, V75I, K219Q | G190S | K101Q, V106VI, K122E, I135L, V245M |
| >1288-30408| codons 38-247 CTELEKEGKISKIGPENPYNTPVFVIKKKNSTRWRKLIDFRELNKRTQDFWEVQLGIPHP AGLQKKKSITVLDVGDAYFSVPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVSSDLEIGQHRTKIEELRQHLLRWGFLTP DQKHQKEPPFLWMGYELHPDKWTVQPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N, M46ML | L33LI, N88D | I13V, A22V, R57K, I62IV, L63P, A71V |
| >1288-30408| codons 4-99 TLWQRPLVTVKIGGQLKEVLLDTGADNTVIEEMNLPGRWKPKLIGGIGGFIKVKQYDQVP IEICGHKVIGTVLVGPTPVNIIGRDLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |