Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1287 | 1287-30407 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | L24I, L33I | L10I, I13V, L19Q, K20M, M36I, D60E, L63P |
| >1287-30407| codons 4-99 TLWQRPIVTVKIGGQQMEALIDTGADDTVIEEINLPGRWKPKIIGGIGGFVKVRQYEQIP IEICGHKAIGTVLVGPTPVNVIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69TADN, M184V, L210W, T215Y | K101P, K103N | K43Q, D123N, I135T, K166R, D177E, G196E, T200A, R211K, D218E |
| >1287-30407| codons 38-247 CTELEQEGKISKIGPENPYNTPVFAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLPKNKSVTVLDVGDAYFSVPLDKNFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTRILEPFRKQNPEIVIYQYVDDLYVGSDLEIEQHRAKIEELRQHLWKWGFYTP EKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |