Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1284 | 1284-30307 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L33F, Q58E, L89V | I13V, I15V, E34Q, L63P, A71V, T74S, V77I, Q92R, I93F |
| >1284-30307| codons 4-99 TLWQRPLVTVKVGGQLKEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFMKVREYDQIP IEICGHKVIGSVLIGPTPVNVIGRNVMTRFGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L74IV, V75M, M184V, L210W, T215Y | E40F, K43E, S68SG, V118I, K122E, I135T, I178M, R211K, V245K |
| >1284-30307| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFAIKKKNGTKWRKVMDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDMVIYQYVDDLYVGSDLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |