Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1466 | 1466-30606 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, G48M, I50V, I54S, V82A, L90M | K43T | L10IV, E34Q, F53Y, I62V, L63P, I64V, A71V, I72V, V77I, I85V, I93L |
| >1466-30606| codons 4-99 TLWQRPVVTIKIGGQLKEALLDTGADDTVLQEMNLPGRWTPKIIMGVGGYSKVRQYDQVP VEICGHKVVGTVLIGPTPANIVGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L74V, T215F | K219Q | K103N | S68SG, K102KR, V118I, K122E, R211Q, F214L, D218E |
| >1466-30606| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNGTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKRNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLQWGLFTP EQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |