Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1465 | 1465-30604 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | V11I, L33F, Q58E | L10IV, I13V, K20R, E35D, M36I, N37E, P39PS, K55R, R57RK, D60E, I62V, L63P, A71V |
| >1465-30604| codons 4-99 TLWQRPVITVKIGGQLREALLDTGADDTVFEDIELSGRWKPKIIGGVGGFVRVKEYEQVP IEICGHKVIGTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74I, M184V, L210W, T215F | Y181C | A98G, V108I | K43N, V118I, K122E, F171Y, V179I, V189VI, Q197E, E203D, Q207E, R211RK, D218DE, K219G, L228H | P170PHQ |
| >1465-30604| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKNSDKWRKIVDFRELNKRTQDFWEVQLGIPHP GGLKKKKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEQYRKQNPDIIICQYVDDLYIGSDLEIGEHRTKIDELREHLWKWGFFTP EGKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |