Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1794 | 1794-30714 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82T, L90M | L10F, K43T, N88D | I13M, L19I, K20R, E35D, M36I, K55R, R57RK, I62V, L63P, I66V, H69Q, A71V, Q92K, I93L, C95F, T96S |
| >1794-30714| codons 4-99 TLWQRPFVTMKIGGQIREALLDTGADDTVLEDINLPGRWTPKIIGGIGGFVRVKQYDQVP IEVCGQKVIGTVLVGPTPTNIIGRDLMTKLGFSLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, T215Y | K219Q | K103N, Y181C | A98G, V108I | V60I, K122E, T200A, E203D, Q207E, R211K, F214FL, D218E, L228H, V245E |
| >1794-30714| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRAKIDELREHLLKWGLYTP EQKHQKEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |