Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1792 | 1792-30529 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | G73T | L10I, K20I, R41K, Q61H, L63P, I64IV, I66IV, A71V, I72V, V77I |
| >1792-30529| codons 4-99 TLWQRPIVTIKIGGQLIEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYDHIP VEVCGHKVVTTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Y115YF, Q151M, M184V, T215F | A62AV, V75VI, F77FL, K219EQ | Y181C, G190GS | A98G, V108I | K49KR, V106VI, K122E, I135IT, T139TA, K173N, Q174K, D177E, V189VI, T200A, I202V, Q207E, R211K, F214L, H221HY, L228H |
| >1792-30529| codons 38-247 CTEMEKEGKISRIGPENPYNTPVFVIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHP GGLKKKKSITILDVGDAFFSVPLDEDFRKYTAFTIPSTNNEAPGIRYQYNVLPMGWKGSP AIFQSSMTKILEPFRNKNPEIVICQYVDDLYISSDLEIGQHRAKVEELREHLLKWGLFTP DQKYQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |