Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1148 | 1148-30325 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L74V, L210W, T215Y | K219R | K101P, Y188L | F227L | T39AE, K43EQ, E44D, V90VI, V118I, K122E, D123DG, I135T, A158S, S162A, V189VI, G196E, E203K, Q207E, H208Y, R211K, K223E, L228H |
| >1148-30325| codons 38-247 CEELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEIQLGIPHP AGLPKKKSVTVLDVGDAYFSIPLDEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP SIFQASMTKILEPFRKQNPDIVIYQYMDDLLIGSDLEIEQHRTKIKELREYLWKWGFYTP DRKHQEEPPLHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | G73S | L10I, I13M, L19T, K20I, E35ED, M36MI, R41RK, K55R, D60E, I62V, L63P, C67F, H69R, A71V, I72IT |
| >1148-30325| codons 4-99 TLWQRPIVTMKIGGQTIEALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVRVRQYEQVP IEIFGRKVTSTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |