<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1148 1148-30325 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, L74V, L210W, T215Y K219R K101P, Y188L F227L T39AE, K43EQ, E44D, V90VI, V118I, K122E, D123DG, I135T, A158S, S162A, V189VI, G196E, E203K, Q207E, H208Y, R211K, K223E, L228H  
>1148-30325| codons 38-247
CEELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKVVDFRELNKRTQDFWEIQLGIPHP
AGLPKKKSVTVLDVGDAYFSIPLDEGFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
SIFQASMTKILEPFRKQNPDIVIYQYMDDLLIGSDLEIEQHRTKIKELREYLWKWGFYTP
DRKHQEEPPLHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M G73S L10I, I13M, L19T, K20I, E35ED, M36MI, R41RK, K55R, D60E, I62V, L63P, C67F, H69R, A71V, I72IT  
>1148-30325| codons 4-99
TLWQRPIVTMKIGGQTIEALLDTGADDTVLEDINLPGKWKPKLIGGIGGFVRVRQYEQVP
IEIFGRKVTSTVLVGPTPANIIGRNLMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006