Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1147 | 1147-30325 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82C, L90M | L10F, G73S | T12A, I13V, I15V, L19P, K20I, E35DN, M36I, N37E, R41K, K55R, L63P, A71V, I72R, I93L |
| >1147-30325| codons 4-99 TLWQRPFVAVKVGGQPIEALLDTGADDTVLENIELPGKWKPKIIGGIGGFVRVRQYDQIP IEICGHKVRSTVLVGPTPCNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, M184V | K70Q | K103N, Y181C, G190A | K101Q, V106I, K122E, I135T, S162C, Q174K, T200A, Q207A, H221Y, L228H, V245K |
| >1147-30325| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDSTQWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKNKSITVLDVGDAFFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILEPFRKKNPDIVICQYVDDLYVASDLEIGQHRAKIEELRAHLLRWGFTTP DKKYQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |