<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1146 1146-30318 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46L, I47V, I54V, V82A, L90M L33F, F53L, L89V L10I, K20KR, E34Q, E35D, M36I, N37D, K55N, L63P, I64M, A71I, I72V, Q92K  
>1146-30318| codons 4-99
TLWQRPIVTIKIGGQLREALLDTGADDTIFQDIDLPGRWKPKLVGGIGGLVNVRQYDQIP
MEICGHKIVGTVLVGPTPANIIGRNVMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74V, M184V, L210W, T215Y K219N L100I, K103N A98G T39TA, K43Q, E44D, V118I, D121H, K122E, S162DN, D177G, G196E, T200A, E203K, H208Y, R211K, K223E, L228H, V245M V111VIM
>1146-30318| codons 38-247
CAELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
GGIKKNKSVTVLDMGDAYFSIPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQNSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTP
DNKHQEEPPFHWMGYELHPDKWTVQPIMLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006