Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1146 | 1146-30318 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I47V, I54V, V82A, L90M | L33F, F53L, L89V | L10I, K20KR, E34Q, E35D, M36I, N37D, K55N, L63P, I64M, A71I, I72V, Q92K |
| >1146-30318| codons 4-99 TLWQRPIVTIKIGGQLREALLDTGADDTIFQDIDLPGRWKPKLVGGIGGLVNVRQYDQIP MEICGHKIVGTVLVGPTPANIIGRNVMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | L100I, K103N | A98G | T39TA, K43Q, E44D, V111VIM, V118I, D121H, K122E, S162DN, D177G, G196E, T200A, E203K, H208Y, R211K, K223E, L228H, V245M |
| >1146-30318| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP GGIKKNKSVTVLDMGDAYFSIPLHEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQNSMTKILEPFRKQNPGIVIYQYVDDLYVGSDLEIEQHRAKIKELRQYLWKWGFYTP DNKHQEEPPFHWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |