Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1444 | 1444-30603 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54T, V82A | L33F | L10V, I13V, K14KR, K20R, N37D, L63P, A71V, I72IM, I93L |
| >1444-30603| codons 4-99 TLWQRPVVTVRIGGQLREALLDTGADDTVFEEMDLPGRWKPKLIVGIGGFTKVRQYDQIP IEICGHKVMGTVLVGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210LW, T215Y | K103NST | T39A, K64R, W88C, K104KR, V111VM, I135V, K166KI |
| >1444-30603| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIRKKDSTKWRKLVDFRELNKRTQDFCEVQLGIPHP AGLKKTRSVTVLDMGDAYFSVPLDKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTIILEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |