Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1440 | 1440-30527 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | L33F, F53L, L89V | L10I, I13V, L19T, K20R, E35D, M36I, N37DE, L63P, I66F, A71V, I93V |
| >1440-30527| codons 4-99 TLWQRPIVTVKIGGQTREALLDTGADDTIFEDIELPGRWKPKIIGGIGGLVKVRQYDQIP IEFCGHKVIGTVLVGPTPANIIGRNVMTQVGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K65R, K70R, Q151M, T215F | V75I, F116Y, K219E | K103S, Y181C, G190A | V108I | S68G, T69TI, L109I, V118I, D123E, I135T, T139I, T165I, Q174H, D177E, I202V, F214L, L228H, I244V, V245M |
| >1440-30527| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKRKDGIRWRKLIDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTIIDVGDAYYSIPLDKEFRKYTAFTIPSTNNEIPGIRYQYNVLPMGWKGSP AIFQSSMIKILEPFRKHNPEIVICQYMDDLYVASDLEIGQHRTKVEELRQHLLRWGLFTP DEKHQKEPPFHWMGYELHPDKWTVQPVMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |